Rare association of Kallman Morsier syndrome with a non-functioning pituitary microadenoma
Department of Endocrinology, Diabetology, Metabolic Diseases Nutrition CHU Mohamed VI, Marrakech, Morocco.
Case Study
World Journal of Advanced Research and Reviews, 2023, 18(01), 217–219
Article DOI: 10.30574/wjarr.2023.18.1.0556
Publication history:
Received on 25 February 2023; revised on 04 April 2023; accepted on 07 April 2023
Abstract:
Kallmann's syndrome (KS) is a form of hypogonadotropic hypogonadism associated with a defect in the sense of smell, due to abnormal migration of gonadotropin-releasing hormone-producing neurons. We report the case of a patient aged 16 years and 6 months who presented a micropenis with poor development of secondary sexual characteristics and anosmia. Plasma levels of luteinizing hormone, follicle stimulating hormone and testosterone were very low, while chromosomal analysis showed a 46XY karyotype. Hypothalamic-pituitary MRI showed bilateral agenesis of the olfactory bulbs associated with a 4 mm pituitary microadenoma. The patient was put on hormone replacement therapy with a good response.
Keywords:
Hypogonadotropic hypogonadism; Kallmann's syndrome; Micropenis; Anosmia
Full text article in PDF:
Copyright information:
Copyright © 2023 Author(s) retain the copyright of this article. This article is published under the terms of the Creative Commons Attribution Liscense 4.0