Effects of aerobic training on oxidative stress and inflammation in rats exposed to controlled emissions of carbon monoxide (CO) and nitrogen dioxide (NO2)
1 Respiratory, Hormonal and Gerontological Sports Explorations Unit. University of Abomey-Calavi (UAC), National Institute of Youth, Physical Education and Sport (INJEPS), Benin.
2 Exercise Physiology and Biomechanics Research Unit, Marien Ngouabi University, Higher Institute of Physical Education and Sport (ISEPS), Congo.
3 Physiology/Pharmacology laboratory, Faculty of Sciences, University of Lomé, BP: 1515 Lomé, Togo.
4 Biomechanics and Performance Laboratory. University of Abomey-Calavi (UAC), National Institute of Youth, Physical Education and Sport (INJEPS), Benin.
Research Article
World Journal of Advanced Research and Reviews, 2020, 08(02), 099-110
Article DOI: 10.30574/wjarr.2020.8.2.0408
Publication history:
Received on 03 November 2020; revised on 08 November 2020; accepted on 11 November 2020
Abstract:
The objective of this study is to determine the effects of isolated exercise and those of repeated exercise on oxidative stress and the inflammatory process following exposure to carbon monoxide (CO) and nitrogen dioxide (NO2).
Material and Method: 15 male Wistar rats, all eight weeks old, were randomly assigned to three groups. CO and NO2 were produced by the combustion of diesel fuel using a device contained in a sealed metal box and supplied with ambient air by a pump. The ranges of CO and NO2 concentrations to which the rats were exposed ranged from 35 to 45 ppm and 0.2 to 0.3 ppm, respectively. The aerobic workouts were performed on a rat treadmill. Blood samples were taken 24 hours after completion of handling at D4, D9 and D14. Variables studied were Malondialdehyde (MDA) and Tumor Necrosis Factor-alpha (TNF-α).
Results: Aerobic endurance training after repeated exposure to CO and NO2 induces at the end of the first training block (D4) a significant increase (p ˂ 0.01) in MDA and TNF-α. On the other hand, the second block (D9) and the third training block (D14) induced a significant decrease (p ˂ 0.01) in these same parameters.
Conclusion: Aerobic exercise practiced in isolation exacerbates the oxidative stress and inflammation induced by exposure to CO and NO2. On the other hand, regular aerobic exercise in a less polluted environment, following five days of recovery, significantly reduces the high levels of oxidative stress and inflammation caused by repeated exposure to automobile pollutants.
Keywords:
Pollution; Aerobic Exercise; Oxidative Stress; Inflammation.
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