EBV as the cause of fever of unknown origin in children

Elda Skenderi 1, *, Gjeorgjina Kuli-Lito ², Alberta Shkembi ³ and Admir Sulovari ⁴

¹ Pediatrician, General Pediatric Ward, University Hospital Center “Mother Tereza”, Tirana, Albania.
² Professor, Chef of Pediatric Infectious Disease Ward, University Hospital Center “Mother Tereza”, Tirana, Albania.
³ Psychologist, University Hospital Center “Mother Tereza”, Tirana, Albania.
⁴ Radiologist, American Hospital Center, Pristina, Kosovo.
 
Research Article
World Journal of Advanced Research and Reviews, 2023, 18(01), 384–389
Article DOI: 10.30574/wjarr.2023.18.1.0599
 
Publication history: 
Received on 28 February 2023; revised on 08 April 2023; accepted on 11 April 2023
 
Abstract: 
EBV is a human herpesvirus which is ubiquitous in nature and infects most of the world population. Children mostly acquire primary EBV infection from close contact that involves exchange of oral secretions. Primary EBV infection in children may go undetected as it is often asymptomatic or is presented with atypical or partial Infectious Mononucleosis syndrome. This study aimed to highlight the role of primary EBV as a cause of Fever of Unknown Origin in childhood. Fever resulted the most common symptom of IM in 97% of children, it was of long duration and correlated with the massive lymphocytosis of primary EBV infection in children. Primary EBV infection is a potential cause of Fever of Unknown Origin in Children.
 
Keywords: 
Fever; EBV; Symptom; Lymphocytosis; FUO
 
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