Clinical- pathological features and surgical outcome of renal cell carcinoma: Experience from a zonal referral hospital-northern of Tanzania
1 Faculty of Medicine, Kilimanjaro Christian Medical University College, P. O. Box 2240, Moshi-Tanzania.
2 Department of Urology, Benjamin Mkapa Hospital, P. O Box 11088, Dodoma-Tanzania
3 Department of Urology, Kilimanjaro Christian Medical Centre, P. O. Box 3010, Moshi-Tanzania.
4 Department of Pathology, Kilimanjaro Christian Medical Centre, P. O. Box 3010, Moshi-Tanzania.
Research Article
World Journal of Advanced Research and Reviews, 2021, 12(02), 434–440
Article DOI: 10.30574/wjarr.2021.12.2.0585
Publication history:
Received on 07 October 2021; revised on 17 November 2021; accepted on 19 November 2021
Abstract:
Background: Renal cell carcinoma (RCC) is the most common primary malignant tumour of kidney in adults. Recent studies from developed countries have shown that most renal tumour are currently diagnosed incidentally during screening for other disease which leads to better prognosis while few studies done in Africa still shows significant proportion of patients present with classic triad ( >10%) which is a sign of advanced disease.
Objectives: This study aimed at determining clinical pathological feature and outcome of RCC in Northern zone of Tanzania.
Patients and Methods: This was a hospital based descriptive retrospective cohort study conducted at Kilimanjaro Christian Medical (KCMC) from January 2002 to December 2017. Data were analysed using statistical package for social science (SPSS) version 16. 0 and summarized in tables and figures.
Results: Forty three patients (43) underwent radical nephrectomy for RCC during the study period. Male to female ratio was1. 7: 1 with mean age of 53+/- 12 years. Flank pain (84%), abdominal mass (76%) and hematuria (44%) were the most common clinical presentation while classical triad was found in 40%. The most common clinical tumor stage was T3(72. 1%) whilst clear cell carcinoma was the commonest histological pattern. Five years survival length for T1, T2, T3 and T4 were 100%, 62. 5%, 32. 3% and 0% respectively.
Conclusion: The most common presenting symptom of RCC in our centre is flank pain, and abdominal mass. Majority of the patients presented with advanced disease with less than five year survival rate. Clear cell type was the predominant histological type.
Keywords:
Renal cell carcinoma; Radical nephrectomy; Histopathology; Surgical Outcome; Tanzania
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