Anti-Dyslipidemia effectiveness of andaliman fruit extract (Zanthoxylum acanthopodium) in Wistar rats given a high fat diet and PTU (Propylthiouracil)
Biomedical Science, Faculty of Medicine, Universitas Prima Indonesia.
Research Article
World Journal of Advanced Research and Reviews, 2023, 18(01), 332–337
Article DOI: 10.30574/wjarr.2023.18.1.0567
Publication history:
Received on 24 February 2023; revised on 06 April 2023; accepted on 08 April 2023
Abstract:
The andaliman fruit contains many phytochemicals, such as phenols, saponins, flavonoids, triterpenoids, and alkaloids, and has various pharmacological effects such as: anti-inflammatory, antioxidant, antidiabetic, and antibacterial. This study aimed to explore the antidislipidemia effectiveness of andaliman fruit extract. This experimental study used the Pre-test and Post-test group-only control design approach using Wistar male rats as experimental animals. The sample size in this study was calculated using the Federer formula; the calculation showed that at least four male Wistar rats (Rattus norvegicus) were needed in each treatment group. First, the research data were analyzed descriptively (Central tendency and Dispersion) of lipid profile data (LDL, HDL, Total cholesterol, and Triglycerides), color, texture, and weight. Then the research data in the form of lipid profiles were analyzed with One-Way Anova if the data were normally distributed with further tests in the form of Post Hoc Tukey HSD tests to see the fundamental differences between treatments. However, if the data were not normally distributed, the Kruskall-Wallis test was used as an alternative. The results showed that the total cholesterol of rats before being given a high-fat diet in all treatment groups did not show significant differences (P value = 0.782). This indicates that all rats' cholesterol data were uniform before being given the high-fat diet. However, after a high-fat diet, total cholesterol in all groups of rats showed different distributions. Only the control, standard, andaliman fruit methanol extract-I, II, and III groups had uniform total cholesterol. The methanol extract of andaliman fruit could significantly reduce total cholesterol, triglyceride, LDL, and SGOT levels compared to the control group. In contrast, the methanol extract of andaliman fruit could dramatically increase HDL levels compared to the control group.
Keywords:
Anti-Dyslipidemia; Andaliman Fruit; Methanol
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